The effects of maternal preeclampsia on inflammatory cytokines and clinical outcomes in premature infants

Maternal preeclampsia & clinical outcomes in premature infants

  • Salih Cagri Cakir Department of Pediatrics, Division of Neonatology, Bursa Uludag University Medical Faculty,
  • Bayram Ali Dorum Uludag University
  • Nilgun Koksal Department of Pediatrics, Division of Neonatology, Bursa Uludag University Medical Faculty,
  • Hilal Ozkan Department of Pediatrics, Division of Neonatology, Bursa Uludag University Medical Faculty,
Keywords: Preeclampsia, Premature, Newborn, Cytokine, Cord blood

Abstract

Objective: To investigate the effects of maternal preeclampsia on inflammatory cytokines and neonatal outcomes in premature infants.

Methods: The study included preterm infants born at gestational age ≤32 weeks in a tertiary university hospital between January 2016 and January 2017. The study group consisted of infants born from mothers with preeclampsia (Group-1), and the control group consisted of infants born from normotensive mothers (Group-2). Demographic characteristics and clinical outcomes of the infants were recorded. IL-6, IL-8, IL-10, and TNF-α cytokine levels were measured from umbilical cord blood samples.

Results: A total of 108 infants were included in the study, of which 34 were in the Group-1 and 74 in the Group-2. Gestational ages (29 vs 30 weeks) of the infants in both groups were similar. There was no significant difference between the cytokine levels of infants with and without preeclampsia. The rate of small for gestational age, retinopathy of prematurity, intraventricular hemorrhage, necrotizing enterocolitis, neutropenia, and thrombocytopenia were significantly higher at the infants with preeclampsia.

Conclusion: Maternal preeclampsia leads to an increase at the neonatal morbidities in premature infants without causing a significant alteration at the cytokine levels in cord blood.

doi: https://doi.org/10.12669/pjms.36.2.1316

How to cite this:
Cakir SC, Dorum BA, Koksal N, Ozkan H. The effects of maternal preeclampsia on inflammatory cytokines and clinical outcomes in premature infants. Pak J Med Sci. 2020;36(2):26-31. doi: https://doi.org/10.12669/pjms.36.2.1316

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published
2019-12-14
How to Cite
Cakir, S. C., Dorum, B. A., Koksal, N., & Ozkan, H. (2019). The effects of maternal preeclampsia on inflammatory cytokines and clinical outcomes in premature infants. Pakistan Journal of Medical Sciences, 36(2). https://doi.org/10.12669/pjms.36.2.1316
Section
Original Articles

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