Expression of p-AMPK in colorectal cancer revealed substantial diverse survival patterns

Expression of p-AMPK in colorectal cancer

  • Mohamad Nidal Khabaz King Abdulaziz University
  • Amer Shafei Abdelrahman
  • Jaudah Ahmad Al-Maghrabi King Abdulaziz University
Keywords: Phosphorylated AMPK, p-AMPK, Immunohistochemistry, Colorectal cancer

Abstract

Objective: Several cancers have showed differences in the role of p- AMPK in cancer growth, progression and prognosis, and little is identified regarding the significance of p-AMPK expression in colorectal adenocarcinoma. Therefore, this report will define p-AMPK phenotype in a panel of colorectal carcinomas and explore the relationship between this phenotype and tumor clinicopathological features.

Methods: A total of 228 cases comprising 155 large intestine cancers and 73 controls (40 benign tumors and thirty three non-cancerous tissues) were employed in tissue microarray construction. Immunohistochemistry (IHC) staining was applied to reveal p-AMPK expression. This study was carried out in the pathology lab of King Abdulaziz University Hospital over a duration of 15 months and was completed on 7th July 2018.

Results: Phosphorylated AMPK was identified in 133 (85.8%) of colorectal cancers and 73 (100%) control cases. Histologic type was noticeably correlated with p-AMPK immunostaining (P= 0.001), high score of p-AMPK immunostaining is more frequent in control cases. Considerable varied survival models were observed with neoplasm size, metastatic tumor, recurrence and disease relapse (P-values <0.01). Survival estimates are considerably healthier in positive cases which have one of the following features size less than 5 cm, absence of metastatic tumor, no reoccurrence or disease relapse.

Conclusions: The present study showed a reduction in the IHC staining of p-AMPK in colorectal cancer compared with controls. IHC staining of p-AMPK can be a supportive marker in predicting prognosis and survival estimates of colorectal tumors with specific clinical factors.

doi: https://doi.org/10.12669/pjms.35.3.159

How to cite this:
Khabaz MN, Abdelrahman AS, Al-Maghrabi JA. Expression of p-AMPK in colorectal cancer revealed substantial diverse survival patterns. Pak J Med Sci. 2019;35(3):685-690. doi: https://doi.org/10.12669/pjms.35.3.159

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Author Biography

Jaudah Ahmad Al-Maghrabi, King Abdulaziz University

Department of Pathology, Faculty of Medicine

King Abdulaziz University

Jeddah, Saudi Arabia.

Published
2019-05-21
Section
Original Articles