Impact of supervised exercise training on pulmonary function parameters, exercise capacity and Irisin Biomarker in Interstitial lung disease patients
Objectives: To assess the impact of supervised exercise training (SET) on pulmonary function Parameters, exercise capacity and Irisin biomarker in Interstitial Lung Disease (ILD) patients.
Methods: Ten (10) patients with ILD and 18 healthy controls of age between 30-40+ years were selected for 8-weekSET program. Before and after SET all subjects performedexercise capacity six minutes’ walk test (6MWT), heart rate (HR) changes were recorded, shortness of Breath Respiratory Questionnaire (SOBQ) was obtained and Irisin levels were measuredby Enzyme-Linked Immunosorbent Assay (ELISA).This interventional study was carried out atDepartment of Physiology, Faculty of Medicine, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia, from October 2018 to February 2019.
Results: Mean six minutes’ walk distance (6MWD) was 395±68.4 m at 1st visit increased significantly (p=0.001) to 458.8±87.1 mat 15 visit. However, 6MWD values found significantly higher in controls (517.4±84.1 m; 561.7±81.6 m; p=0.013) thanILD patients. Overall change (difference between post and pre exercise) in HRvalue was recorded lower in ILD patients (30-35 bpm) as compared to controls (40-45 bpm). Moreover, ILD patients had overall higher SOBQ score than controls. Pre SET Irisin levelsofILD patients (4.24 ± 1.73 pg/ml) and controls (3.43±1.04pg/ml) werefound unchangedafter SET (4.48±2.02pg/ml, 3.39 ±1.41pg/ml,p=0.677, p=0.093) respectively. However, patients Irisin values were foundhigher as compared to controls before and after SET.
Conclusion: Exercise capacity and Dyspneain patients with ILD were improved after 8-week of SET program. No major changes in Irisin levels among patients with ILD and controls were observed. Additional research requires to be carried out on large number of subjects to deterMinutese the advantages of exercise in ILD.
How to cite this:
Alyami RM, Alhwaikan AM, Alharbi AR, AL-Nafisah G. Impact of supervised exercise training on pulmonary function parameters, exercise capacity and Irisin Biomarker in Interstitial lung disease patients. Pak J Med Sci. 2020;36(5):1089-1095. doi: https://doi.org/10.12669/pjms.36.5.1795
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