Risk factors of knee osteoarthritis: A case-control study

Risk factors of knee osteoarthritis

  • Nasrin Moghimi 1. Assistant Professor of Rheumatology, Dept. of Rheumatology, Kurdistan University of Medical Sciences, Sanandaj, Iran.
  • Khaled Rahmani 2. Assistant professor of Epidemiology, Dept of Community Medicine , Kurdistan University of Medical Sciences, Sanandaj, Iran
  • Ali Delpisheh Professor of Clinical Epidemiology, Ilam University of Medical Sciences, Ilam, Iran
  • Afshin Saidi Liver & Digestive Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran
  • Namam Ali Azadi Biostatistics Department, School of public health, Iran University of Medical Sciences, Tehran, Iran
  • Abdorrahim Afkhamzadeh Social Determinants of Health Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran
Keywords: Risk factors, Knee osteoarthritis, COPCORD study


Background and Objective: Knee osteoarthritis is one of the most common rheumatologic problems. To investigate risk factors related to the knee osteoarthritis a case-control study was performed using cases diagnosed in the Community Oriented Program for Control of Rheumatic Diseases (COPCORD) study, stage I.

Methods: Using data from the 2012 COPCORD study, stage-I that was conducted in Sanandaj, northwestern of Iran, we runned a case-control study in 2014-2015. Cases were 700 knee osteoarthritis using American College of Rheumatology (ACR) criteria, frequency matched with 700 healthy controls that were randomly selected from the general population.

Results: In multivariate analysis, statistical significant relation was observed between knee OA and some studied factors such as body mass index (P <0.001), lodging (living in highland vs. plain) (P <0.001), type of used toilet (regular vs. toilet) (P <0.001), history of using high-heeled shoes (>3 cm) (P = 0.005), history of knee Injury (P = 0.04), history of lower limb fracture (P = 0.02), Number of pregnancies (P <0.001) and history of pain and swelling (lasting for one months) (P = 0.04).

Conclusions: Living in highland area, using regular toilet, having knee injury and lower limb fracture in the past were most significant associated factors with occurrence of knee osteoarthritis.

doi: https://doi.org/10.12669/pjms.35.3.277

How to cite this:
Moghimi N, Rahmani K, Delpisheh A, Saidi A, Azadi NA, Afkhamzadeh A. Risk factors of knee osteoarthritis: A case-control study. Pak J Med Sci. 2019;35(3):636-640. doi: https://doi.org/10.12669/pjms.35.3.277

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

How to Cite
Moghimi, N., Rahmani, K., Delpisheh, A., Saidi, A., Azadi, N. A., & Afkhamzadeh, A. (2019). Risk factors of knee osteoarthritis: A case-control study. Pakistan Journal of Medical Sciences, 35(3). https://doi.org/10.12669/pjms.35.3.277
Original Articles