Risk factors of knee osteoarthritis: A case-control study

Risk factors of knee osteoarthritis

  • Nasrin Moghimi 1. Assistant Professor of Rheumatology, Dept. of Rheumatology, Kurdistan University of Medical Sciences, Sanandaj, Iran.
  • Khaled Rahmani 2. Assistant professor of Epidemiology, Dept of Community Medicine , Kurdistan University of Medical Sciences, Sanandaj, Iran
  • Ali Delpisheh Professor of Clinical Epidemiology, Ilam University of Medical Sciences, Ilam, Iran
  • Afshin Saidi Liver & Digestive Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran
  • Namam Ali Azadi Biostatistics Department, School of public health, Iran University of Medical Sciences, Tehran, Iran
  • Abdorrahim Afkhamzadeh Social Determinants of Health Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran
Keywords: Risk factors, Knee osteoarthritis, COPCORD study


Background and Objective: Knee osteoarthritis is one of the most common rheumatologic problems. To investigate risk factors related to the knee osteoarthritis a case-control study was performed using cases diagnosed in the Community Oriented Program for Control of Rheumatic Diseases (COPCORD) study, stage I.

Methods: Using data from the 2012 COPCORD study, stage-I that was conducted in Sanandaj, northwestern of Iran, we runned a case-control study in 2014-2015. Cases were 700 knee osteoarthritis using American College of Rheumatology (ACR) criteria, frequency matched with 700 healthy controls that were randomly selected from the general population.

Results: In multivariate analysis, statistical significant relation was observed between knee OA and some studied factors such as body mass index (P <0.001), lodging (living in highland vs. plain) (P <0.001), type of used toilet (regular vs. toilet) (P <0.001), history of using high-heeled shoes (>3 cm) (P = 0.005), history of knee Injury (P = 0.04), history of lower limb fracture (P = 0.02), Number of pregnancies (P <0.001) and history of pain and swelling (lasting for one months) (P = 0.04).

Conclusions: Living in highland area, using regular toilet, having knee injury and lower limb fracture in the past were most significant associated factors with occurrence of knee osteoarthritis.

doi: https://doi.org/10.12669/pjms.35.3.277

How to cite this:
Moghimi N, Rahmani K, Delpisheh A, Saidi A, Azadi NA, Afkhamzadeh A. Risk factors of knee osteoarthritis: A case-control study. Pak J Med Sci. 2019;35(3):636-640. doi: https://doi.org/10.12669/pjms.35.3.277

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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