Muscle weakness assessment in non-hypoxemic COPD out-patients at tertiary care hospitals

  • Faisal Faiyaz Zuberi DUHS
  • Bader Faiyaz Zuberi Dow University of Health Sciences, Karachi https://orcid.org/0000-0001-7695-3922
  • Faiza Sadaqat Ali Dow University of Health Sciences, Karachi
  • Nimrah Bader University of Oklahoma Health Sciences Center
Keywords: Sarcopenia, Hand grip strength, Chair to stand time, BMI, FEV1

Abstract

Objective: To determine frequency of Muscle Weakness in Non-Hypoxemic COPD out-patients and Comparison with age matched non-COPD Controls.

Methods: This cross-sectional study was conducted at OPD of Ojha Institute of Chest Diseases and Medicine, Dow University of Health Sciences, Karachi, Pakistan, during the period 8th September 2019 till 30th May 2020. Patients of both genders aged 25-70 years who were satisfying GOLD criteria for COPD and having SpO2 ≥ 94% were included. An age matched control group was added as control. Hand Grip Strength (HGS) and Chair to Stand time (CST) were recorded.

Results: Two hundred fifty-six patients were inducted with aged and BMI matched group of non-COPD Control patients in ratio of 1:2 (n = 128). Comparison of HGS between Control and COPD Groups showed significant weakness in COPD group. Significant weakness in lower limbs in COPD Group with longer timings to complete the task. Mean FEV1 had significant low values in COPD Group. Age correlated negatively with HGS & positively with CST. BMI correlated positively with FEV1 and CST but negatively with HGS. HGS correlated positively with FEV1 and no correlation was found with CST. No correlation was found of CST with FEV1.

Conclusion: Muscle weakness in COPD patients was shown by simple validated bedside tools. The older COPD patients had less HGS and were slower in doing CST whereas those COPD ones who had higher FEV1 had more HGS.

Abbreviations:
COPD: Chronic Obstructive Pulmonary Disease, BMI: Body Mass Index, FEV: Forced Expiratory Volume in first second, GOLD: Global Initiative for Chronic Obstructive Lung Disease, HGS: Hand Grip Strength, CST: Chair to Stand Time.

doi: https://doi.org/10.12669/pjms.37.2.3127

How to cite this:
Zuberi FF, Zuberi BF, Ali FS, Bader N. Muscle weakness assessment in non-hypoxemic COPD out-patients at tertiary care hospitals. Pak J Med Sci. 2021;37(2):---------. doi: https://doi.org/10.12669/pjms.37.2.3127

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Author Biographies

Bader Faiyaz Zuberi, Dow University of Health Sciences, Karachi

Professor Medicine

Dow Medical College

Faiza Sadaqat Ali, Dow University of Health Sciences, Karachi

Senior Registrar

Dow Medical College

Nimrah Bader, University of Oklahoma Health Sciences Center

Department of Internal Medicine

Oklahoma City, OK, USA

Published
2021-01-02
How to Cite
Zuberi, F., Zuberi, B., Ali, F., & Bader, N. (2021). Muscle weakness assessment in non-hypoxemic COPD out-patients at tertiary care hospitals. Pakistan Journal of Medical Sciences, 37(2). https://doi.org/10.12669/pjms.37.2.3127
Section
Original Articles