Time to negative PCR in various disease categories of COVID-19 infection in Pakistani population

  • Kaleem Ullah Toori KRL Hospital
  • Asma Chaudhry Southend University Hospital
  • Muhammad Arsalan Qureshi KRL Hospital
Keywords: Corona Virus Induced Disease (COVID-19), SARS-CoV-2, age, gender, pre-morbidities, disease severity, time to negative PCR

Abstract

Objectives: To identify association of epidemiological characteristics, presence of underlying pre-morbidities and disease severity with time to first negative PCR in Corona virus disease 2019.

Methods: Total 842 Corona Virus Real Time Polymerase-Chain-Reaction positive patients were included in this cross-sectional study. Patients were admitted to Department of Medicine at KRL Hospital Islamabad from April to August 2020. Age, gender, symptoms, pre-morbidities and disease severity were recorded. Outcome (recovered versus died) was documented. World Health Organization categories to classify disease severity (asymptomatic, mild, moderate and severe) were used. Time to negative PCR was documented as time between first positive PCR to first negative PCR.

Results: The mean age of patients was 39.04 ± 11.32 years with 99.8% being males. Majority of patients (78.4%) were asymptomatic. Amongst symptoms, fever was the most common symptom. Diabetes mellitus and hypertension were the most commonly recorded co-morbidity. Mean time to negative PCR was 8.8 ± 3.1 days. A large proportion of patients recovered (99.9%). Significant positive correlation (p value < 0.05) was found between age, gender, presence of underlying pre-morbidities and disease severity categories with time to first negative PCR.

Conclusion: The underlying epidemiological factors, pre-morbidities and disease severity are associated with time to negative PCR and hence affect frequency of recovery samples.

doi: https://doi.org/10.12669/pjms.38.1.4476

How to cite this:
Toori KU, Chaudhry A, Qureshi MA. Time to negative PCR in various disease categories of COVID-19 infection in Pakistani population. Pak J Med Sci. 2022;38(1):243-247. doi: https://doi.org/10.12669/pjms.38.1.4476

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Author Biographies

Kaleem Ullah Toori, KRL Hospital

Consultant Physician

Asma Chaudhry, Southend University Hospital

Department of Medicine and Endocrinology

Southend University Hospital, Southend-on-Sea,United Kingdom

Published
2021-11-22
How to Cite
Toori, K. U., Chaudhry, A., & Qureshi, M. A. (2021). Time to negative PCR in various disease categories of COVID-19 infection in Pakistani population. Pakistan Journal of Medical Sciences, 38(1). https://doi.org/10.12669/pjms.38.1.4476
Section
Original Articles