The relationship of 1,25-dihydroxyvitamin D and Vitamin D binding protein in periodontitis

  • Sara Rafique Jinnah Medical & Dental College
  • Mozaffer Rahim Hingorjo Jinnah Medical & Dental College
  • Mahparah Mumtaz Jinnah Medical & Dental College
  • Masood Anwar Qureshi Dow University of Health Sciences
Keywords: Periodontitis, Vitamin D, Vitamin D binding protein


Objective: This study was conducted to explore the relationship between 1,25-dihydroxy vitamin D (1,25(OH)2D) and Vitamin-D binding protein (DBP) in patients with periodontitis and healthy controls.

Methods: Seventy-five periodontitis cases were recruited from the dental OPD of Dow University of Health Sciences, Karachi. Diagnostic criteria of periodontitis were followed according to the probe pocket depth and clinical attachment loss. Seventy-five periodontal healthy controls were selected from the faculty and students of same university. Serum levels of 1,25(OH)2D and DBP were determined by ELISA.

Results: Significantly low levels of 1,25(OH)2D and high levels of serum DBP were observed in periodontitis patients compared to healthy controls (p<0.05), with levels of DBP increasing significantly with the severity of periodontitis (p=0.005). Concentrations of DBP correlated positively with 1,25(OH)2D, especially in cases with periodontitis (r =0.780; p<0.001).

Conclusion: Within the limits of the study, we conclude that low 1,25(OH)2D levels and high DBP levels are associated with periodontitis.


How to cite this:
Rafique S, Hingorjo MR, Mumtaz M, Qureshi MA. The relationship of 1,25-dihydroxyvitamin D and Vitamin D binding protein in periodontitis. Pak J Med Sci. 2019;35(3):847-851. doi:

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Author Biographies

Sara Rafique, Jinnah Medical & Dental College

MPhil in Physiology

Senior Lecturer

Department of Physiology

Mahparah Mumtaz, Jinnah Medical & Dental College


Senior Lecturer

Department of Physiology

Masood Anwar Qureshi, Dow University of Health Sciences


Professor of Physiology

Department of Physiology

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