Clinical effects of continuous veno-venous hemofiltration combined with hemoperfusion for the treatment of multiple myeloma complicated with acute kidney injury

Jing Huang; Fengping Qiu; Huiqi Zhang; Xiangli Shen; Xia Lin

doi:10.12669/pjms.39.2.6966

Jing Huang
Fengping Qiu The First People's Hospital of Huzhou City
Huiqi Zhang
Xiangli Shen
Xia Lin

DOI: https://doi.org/10.12669/pjms.39.2.6966

Keywords: Continuous veno-venous hemofiltration, Hemoperfusion, Multiple myeloma, Acute Kidney injury, Kidney function

Abstract

Objective: To evaluate the clinical efficacy of continuous veno-venous hemofiltration (CVVH) combined with hemoperfusion for the treatment of multiple myeloma (MM) complicated with acute kidney injury (AKI).

Methods: Medical records of 73 patients with MM complicated with AKI admitted to the First People’s Hospital of Huzhou from January 2019 to January 2021 were retrospectively analyzed. According to the treatment records, 35 patients received simple chemotherapy (control group), and 38 patients received CVVH combined with HP on the basis of chemotherapy (observation group). We compared the clinical efficacies, renal function indexes, and the serum globulin and erythrocyte sedimentation rate (ESR) values between the two groups.

Results: After the treatment, the total efficacy of the observation group was significantly higher (81.58%) than that in the control group (57.14%; p <0.05). Serum cystatin C (CysC), urea nitrogen (BUN), β2 macroglobulin (β2-MG) and creatinine (SCr) levels were significantly lower in the observation group than in the control group (p <0.05). Serum globulin level and ESR values in the observation group after the treatment were also significantly lower than in the control group (p <0.05).

Conclusions: The outcomes of patients with MM complicated with AKI treated with CVVH and hemoperfusion differ significantly from those of the patients treated only with CVVH. Combining CVVH and hemoperfusion helps to improve the efficacy of the treatment, promotes renal function recovery, and improves the levels of serum globulin and ESR.

doi: https://doi.org/10.12669/pjms.39.2.6966

How to cite this: Huang J, Qiu F, Zhang H, Shen X, Lin X. Clinical effects of continuous veno-venous hemofiltration combined with hemoperfusion for the treatment of multiple myeloma complicated with acute kidney injury. Pak J Med Sci. 2023;39(2):344-348. doi: https://doi.org/10.12669/pjms.39.2.6966

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.