@article{Khabaz_Abdelrahman_Al-Maghrabi_2019, title={Expression of p-AMPK in colorectal cancer revealed substantial diverse survival patterns: Expression of p-AMPK in colorectal cancer}, volume={35}, url={https://www.pjms.org.pk/index.php/pjms/article/view/159}, DOI={10.12669/pjms.35.3.159}, abstractNote={<p><em><strong>Objective:</strong></em> Several cancers have showed differences in the role of p- AMPK in cancer growth, progression and prognosis, and little is identified regarding the significance of p-AMPK expression in colorectal adenocarcinoma. Therefore, this report will define p-AMPK phenotype in a panel of colorectal carcinomas and explore the relationship between this phenotype and tumor clinicopathological features.</p> <p><em><strong>Methods:</strong></em> A total of 228 cases comprising 155 large intestine cancers and 73 controls (40 benign tumors and thirty three non-cancerous tissues) were employed in tissue microarray construction. Immunohistochemistry (IHC) staining was applied to reveal p-AMPK expression. This study was carried out in the pathology lab of King Abdulaziz University Hospital over a duration of 15 months and was completed on 7th July 2018.</p> <p><em><strong>Results:</strong></em> Phosphorylated AMPK was identified in 133 (85.8%) of colorectal cancers and 73 (100%) control cases. Histologic type was noticeably correlated with p-AMPK immunostaining (P= 0.001), high score of p-AMPK immunostaining is more frequent in control cases. Considerable varied survival models were observed with neoplasm size, metastatic tumor, recurrence and disease relapse (P-values &lt;0.01). Survival estimates are considerably healthier in positive cases which have one of the following features size less than 5 cm, absence of metastatic tumor, no reoccurrence or disease relapse.</p> <p><em><strong>Conclusions:</strong></em> The present study showed a reduction in the IHC staining of p-AMPK in colorectal cancer compared with controls. IHC staining of p-AMPK can be a supportive marker in predicting prognosis and survival estimates of colorectal tumors with specific clinical factors.</p> <p><strong>doi: https://doi.org/10.12669/pjms.35.3.159</strong></p> <p><em><strong>How to cite this:</strong></em><br>Khabaz MN, Abdelrahman AS, Al-Maghrabi JA. Expression of p-AMPK in colorectal cancer revealed substantial diverse survival patterns. Pak J Med Sci. 2019;35(3):685-690. doi: https://doi.org/10.12669/pjms.35.3.159</p> <p>This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</p&gt;}, number={3}, journal={Pakistan Journal of Medical Sciences}, author={Khabaz, Mohamad Nidal and Abdelrahman, Amer Shafei and Al-Maghrabi, Jaudah Ahmad}, year={2019}, month={May} }