@article{Zhang_Xu_Wei_Shang_2020, title={Clinical study of different doses of atorvastatin combined with febuxostat in patients with gout and carotid atherosclerosis}, volume={36}, url={https://www.pjms.org.pk/index.php/pjms/article/view/2945}, DOI={10.12669/pjms.36.6.2945}, abstractNote={<p><em><strong>Objective:</strong></em> To evaluate the efficacy of atorvastatin combined with febuxostat in the treatment of gout patients with carotid atherosclerosis and to observe the effects on serum tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and C-reactive protein (CRP) levels, carotid plaques, and the adverse reactions.</p> <p><em><strong>Methods:</strong></em> Seventy patients with gout and carotid atherosclerosis admitted to Affiliated Hospital of Hebei University from January 2014 to June 2017 were randomly divided into a treatment group and a control group. The treatment group received oral febuxostat 40 mg/day combined with atorvastatin 40 mg/day. The control group was given 40 mg/day febuxostat combined with 20 mg/day atorvastatin for 90 days. The effects of treatment on TNF-α, IL-1β, and CRP levels and carotid plaques of the patients were observed.</p> <p><em><strong>Results:</strong></em> After 90 days of treatment, serum TNF-α, IL-1β, and CRP levels, as well as HUA and total cholesterol (TC), decreased in both groups after treatment. There were significant differences observed (p &lt; 0.05). The carotid artery plaques in the two groups were significantly smaller after treatment (P&lt;0.05). There was no significant difference in adverse reactions between the two groups (P &gt; 0.05).</p> <p><em><strong>Conclusion:</strong></em> Double doses of atorvastatin combined with febuxostat can effectively reduce uric acid to improve the inflammatory state in patients and reduce carotid plaques without increasing the incidence of adverse reactions.</p> <p><strong>doi: https://doi.org/10.12669/pjms.36.6.2945</strong></p> <p><em><strong>How to cite this:</strong></em><br>Zhang Z, Xu MH, Wei FJ, Shang LN. Clinical study of different doses of atorvastatin combined with febuxostat in patients with gout and carotid atherosclerosis. Pak J Med Sci. 2020;36(6):1334-1338. doi: https://doi.org/10.12669/pjms.36.6.2945</p> <p>This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</p&gt;}, number={6}, journal={Pakistan Journal of Medical Sciences}, author={Zhang, Zheng and Xu, Ming-hua and Wei, Feng-ju and Shang, Li-na}, year={2020}, month={Aug.} }