Effectiveness of pancreatitis activity score plus coagulation function and serum calcium in predicting the severity and outcome of acute pancreatitis

Abstract

Objective: To examine the relationship between acute pancreatitis (AP) severity and both coagulation function and serum calcium levels.

Methodology: This is a retrospective study. A total of one hundred patients with AP admitted to our hospital from July 2022 to January 2024. Fifty patients with severe AP(SAP) were assigned to the experimental group, fifty patients with mild-to-moderate AP were assigned to the control group. The pancreatitis activity score system(PASS) score, platelet(PLT) count, von Willebrand factor antigen(vWF:Ag), prothrombin time(PT), activated partial prothrombin time, fibrinogen, thrombin time, antithrombin III(ATIII), plasminogen, serum calcium(Ca) and D-dimer(D-D) were compared. The independent risk factors for predicting AP severity were analysed. The prognostic predictive value and diagnostic efficacy of these independent risk factors were assessed.

Results: The experimental group exhibited a statistically significant increase in the PASS score, vWF:Ag, PT and D-D levels and a significant decrease in PLT, ATIII and Ca levels compared with the control group(P< 0.001). Logistic regression analysis showed that PASS, vWF:Ag, PT, ATIII, D-D and Ca were independent risk factors for predicting the severity of AP; Ca levels had the highest diagnostic efficacy, followed by ATIII and PT; vWF:Ag was the least effective. The levels of vWF:Ag, PT, and D-D are positively correlated with PASS scores, the levels of ATIII and Ca are negatively correlated.

Conclusion: The levels of vWF:Ag, PT, D-D, ATIII, and Ca in AP patients are correlated with the severity of the condition, and Ca levels may more accurately and early assess the severity of AP patients.