Predictive value of thrombotic molecular markers combined with venous thromboembolism score for thrombosis in patients with gastrointestinal malignancies
DOI:
https://doi.org/10.12669/pjms.41.11.12231Keywords:
gastrointestinal malignancy, venous thrombosis, thrombotic molecular marker, VTE score, predictive valueAbstract
Objective: To investigate the predictive value of thrombotic molecular markers, including TAT, PIC, TM, and t‐PAIC, combined with the VTE score for venous thrombosis in patients with gastrointestinal malignancies.
Methodology: This was a retrospective study. Two hundred and fifteen patients diagnosed with gastrointestinal malignancies at the Affiliated Hospital of Hebei University between January 2024 and March 2025 were enrolled in this study. Based on whether venous thrombosis occurred during hospitalization after treatment, patients were divided into a thrombosis group(n= 34) and a non‐thrombosis group(n= 181). The levels of thrombotic molecular markers, including TAT, PIC, TM, and t‐PAIC, were measured, and the VTE score was recorded for both groups.
Results: The levels of TAT, PIC were significantly higher in the thrombosis group compared to the non-thrombosis group(P<0.05, respectively). ROC curve analysis showed that the area under the curve(AUC) for TAT, PIC, TM, t‐PAIC, VTE score, and the integrated model were 0.774, 0.635, 0.539, 0.573, 0.577, and 0.793, respectively. The AUC of the integrated model was significantly higher than that of TAT, PIC, TM, t‐PAIC, and the VTE score alone(P< 0.05, respectively). At the optimal cutoff value of 0.204, the integrated model achieved a sensitivity of 0.676 and a specificity of 0.851. Multivariate logistic regression analysis identified age, history of cardiovascular disease, and TAT as independent risk factors for VTE (P < 0.05, respectively). Each unit increase in TAT was associated with a 28.9% higher risk of venous thrombosis in patients with gastrointestinal malignancies.
Conclusion: The combination of thrombotic molecular markers and VTE score has significant clinical value in predicting venous thrombosis in patients with gastrointestinal malignancies. This approach facilitates the early identification of high-risk patients.
