Clinical diagnostic value of the plasma heparin binding protein in diabetic nephropathy patients comorbid with sepsis

Abstract

Objective: To explore the clinical diagnostic value of plasma heparin binding protein in diabetes nephropathy (DN) with sepsis.

Methodology: The study was a retrospective study of 82 patients with DN, carried out in Affiliated Hospital of Hebei University from April 2024 to December 2024. Information about inflammatory indicators, biochemical, glucose metabolism and urine microalbumin indicators. Patients were divided into two major groups, DN sepsis group (n=42) and DN group (n=40). Date of 40 T2DM patients were used as the normal control group. The inter group comparison was conducted using analysis of variance, Pearson correlation analysis was used to analyze the correlation between HBP and BUN, Scr, UACR, and eGFR, and receiver operating characteristic (ROC) curve analysis was used to evaluate the specificity and sensitivity of inflammatory indicators, and to evaluate their diagnostic efficiency for DN patients with sepsis.

Results: Compared with DN and T2DM groups, HBP, CRP and PCT were dramatically increased in DN sepsis group (p＜0.001), ESR and NE% also higher (p＜0.05). In DN group, HBP exhibited an upward trend (p＜0.05) than T2DM group. The serum HBP was positively correlated with BUN, Scr and UACR, negatively correlated with eGFR in DN patients. In the early stage of sepsis in DN patients, the area under the curve (AUC) of HBP is 0.691.

Conclusion: The plasma HBP were dramatically increased in DN patients comorbid with sepsis, plasma HBP clinical testing were essential and had high-efficiency clinical diagnosis abilities of sepsis in DN patients.