Diagnostic accuracy of ultrasound in evaluation of obstructive jaundice with MRCP as gold standard

Accuracy of ultrasound in obstructive jaundice

  • Hina Hanif Dow University of Health Sciences
  • Sohail Ahmed Khan
  • Sobia Muneer
  • Syed Omair Adil
Keywords: Obstructive jaundice, Ultrasound, Choledocholithiasis, MRCP, Sensitivity

Abstract

Objective: To evaluate the diagnostic accuracy of ultrasound in obstructive jaundice taking MRCP as gold standard.

Methods: This cross-sectional study was conducted at Dow Institute of Radiology (DIR), Dow University of Health Sciences (DUHS), Karachi from 2nd May 2018 till 2nd November 2018. Both male and female patients aged 30 to 80 years with suspected obstructive jaundice were included. Patients already diagnosed with obstructive jaundice were excluded. MRCP and ultrasound were performed in suspected patients. Diagnostic accuracy including sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of obstructive jaundice were calculated using contingency tables using MRCP findings as gold standard.

Results: Mean age of the patients was 54.73 ± 12.65 years. In causes of obstruction, choledocholothiasis was responsible for 85 (35.1%), stricture 61 (25.2%), carcinoma of head of pancreas 39 (16.1%), periampullary carcinoma 21 (8.7%), cholangiocarcinoma 10 (4.1%) and gallbladder carcinoma 26 (10.7%) of the cases. Diagnostic accuracy of ultrasound in obstructive jaundice taking MRCP findings as gold standard showed sensitivity, specificity, positive predicted value (PPV), negative predicted value (NPV) and overall diagnostic accuracy as 84.57%, 79.10%, 91.36%, 66.25% and 83.06%.

Conclusion: Ultrasound has a high sensitivity, moderate specificity, and high diagnostic accuracy in diagnosis of obstructive jaundice.

doi: https://doi.org/10.12669/pjms.36.4.1665

How to cite this:
Hanif H, Khan SA, Muneer S, Adil SO. Diagnostic accuracy of ultrasound in evaluation of obstructive jaundice with MRCP as gold standard. Pak J Med Sci. 2020;36(4):652-656. doi: https://doi.org/10.12669/pjms.36.4.1665

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published
2020-05-13
How to Cite
Hanif, H., Khan, S., Muneer, S., & Adil, S. (2020). Diagnostic accuracy of ultrasound in evaluation of obstructive jaundice with MRCP as gold standard. Pakistan Journal of Medical Sciences, 36(4). https://doi.org/10.12669/pjms.36.4.1665
Section
Original Articles