Differential expression of e-cadherin in lobular and ductal carcinoma of breast in an Iranian Cancer Care Hospital

Authors

  • Alireza Abdollahi
  • Ensani F
  • Maleki Z
  • Iravanlo G
  • Ashtari A

Keywords:

Ductal carcinoma, Lobular carcinoma, E-cadherin, Breast.

Abstract

Objective: To determine the role of E-cadherin in differentiating Breast lobular carcinoma from Breast ductal carcinoma in Iranian patients.

Methodology: A total of 80 malignant breast samples were reviewed by two pathologists before undergoing E-cad immunohistochemistry (IHC) staining. The results from IHC were compared with the results from the morphological study of the samples and they were then analyzed statistically.

Results: The normal ductal cells had strong complete homogenous membrane E-cadherin reactivity in all cases. The complete absence of E-cadherin membrane staining occurred in 14 out of 16 cases of Lobular breast carcinoma. The mean score of E-cadherin expression in ductal carcinoma was 191.35 with a CV of 104.39. In lobular carcinoma, the mean score of E-cadherin was 9.36 with a CV of 25.68. Using the Mann

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Published

2011-01-20

How to Cite

Abdollahi, A., F, E., Z, M., G, I., & A, A. (2011). Differential expression of e-cadherin in lobular and ductal carcinoma of breast in an Iranian Cancer Care Hospital. Pakistan Journal of Medical Sciences, 27(1), 56–59. Retrieved from https://www.pjms.org.pk/index.php/pjms/article/view/17042

Issue

Vol. 27 No. 1 (2011): January - March 2011 Pak J Med Sci

Section

Original Articles