Metastatic Prostate and renal cell carcinoma presenting as supra-clavicular lymphadenopathy: Report of two cases

Abstract

Most metastases of cancers to cervical lymph nodes including supra-clavicular chain are from the head and neck primary tumors. Cancers metastasizing to the supra-calvicular lymph nodes from non-head and neck origin are rare. This occurs most frequently with lung, breast and esophagus. For prostate cancer, the non-regional lymph nodal involvment is very rarely reported. Similarly renal cell carcinoma presents mostly in advanced stage disease with involvment of non-regional lymph nodes is much less common. We present two cases of prostate and renal cell carcinoma who presented with initial manifestation of supraclavicular lymphadenopathy.