A comparison of anastrozole and clomiphene citrate for ovulation induction in women with unexplained infertility undergoing intrauterine insemination

Authors

  • Taravat Fakheri
  • Hamidreza Saeidiborojeni
  • Mansour Rezaei
  • Farahnaz Keshavarzi
  • Salma Hoseni
  • Sara Daeichin

Keywords:

Anastrozole, clomiphene citrate, Intrauterine insemination, Infertility

Abstract

Objective: In order to overcome the undesirable effects of clomiphene citrate (CC) alternative regimens such as Aromatase inhibitors (AIs) have been recommended. Our objective was to compare the ovarian and endometrial effects of three day Anastrozole and clomiphene citrate in combination with gonadotropin in IUI cycles.
Methodology: This was a prospective descriptive study in 55 infertile patients with unexplained infertility. The patients in Group A (29 patients) received CC and gonadotropin, in contrast to group B (26 patients) who received Anastrozole and gonadotropin. Primary outcome was the size and number of mature follicles together with endometrial thickness.
Results: On the day of HCG administration Anastrozole group developed fewer mature follicles (0.54

Published

2011-12-09

How to Cite

Fakheri, T., Saeidiborojeni, H., Rezaei, M., Keshavarzi, F., Hoseni, S., & Daeichin, S. (2011). A comparison of anastrozole and clomiphene citrate for ovulation induction in women with unexplained infertility undergoing intrauterine insemination. Pakistan Journal of Medical Sciences, 27(5). Retrieved from https://www.pjms.org.pk/index.php/pjms/article/view/17279

Issue

Vol. 27 No. 5 (2011): October - December 2011 Pak J Med Sci

Section

Original Articles