Changes of plasma angiogenic factors during Chronic resistance exercise in Type I Diabetic Rats

Abstract

Objective: Exercise has several beneficial effects on cardiovascular system. However, the exact mechanism is unclear. The purpose of this study was to evaluate the effects of chronic resistance exercise on some plasma angiogenic factors in type 1 diabetic rats.
Methodology: Thirty male Wistar rats were divided into three groups of control, diabetic and diabetic trained (n = 10 each). Diabetes was induced by a single intraperitoneal injection of streptozotocin (55 mg/kg). The rats in the trained group undertook one training session per day, 3 days/week, for 4 weeks. Blood samples were taken and the concentrations of plasma glucose, lipid profile, nitric oxide (NO), vascular endothelial growth factor (VEGF) and soluble form of VEGF receptor-1 (sFlt-1) were determined.
Results: We found a significant reduction in plasma NO concentrations in diabetic rats compared to the controls (p < 0.05). After four weeks of resistance training, plasma NO concentrations increased (p < 0.05). Plasma VEGF concentrations were not significantly different between diabetic and control groups (p < 0.05). However, plasma sFlt-1 concentrations in diabetic rats were significantly higher than the controls (p > 0.05). There were no significant differences in plasma VEGF and sFlt-1 concentrations between diabetic sedentary and trained groups (p > 0.05). Moreover, VEGF/sFlt-1 ratios in diabetic animals were lower than the control group and resistance exercise could not increase this ratio in diabetic animals (p > 0.05)