Genetic polymorphism of agr Locus and antibiotic resistance of Staphylococcus aureus at two hospitals in Pakistan

Authors

  • Sadia Khan Department of Microbiology Quaid-i-Azam University Islamabad, Pakistan
  • Faisal Rasheed Department of Microbiology Quaid-i-Azam University Islamabad, Pakistan
  • Rabaab Zahra Department of Microbiology Quaid-i-Azam University Islamabad, Pakistan

DOI:

https://doi.org/10.12669/pjms.301.4124

Keywords:

S. aureus, agr, MRSA, MSSA.

Abstract

Objective: The accessory gene regulator (agr) locus in Staphylococcus aureus (S. aureus) is a global regulator of quorum sensing and controls the production of virulence factors. This study was carried out to investigate the agr specific groups both in methicillin resistant and sensitive Staphylococcus aureus (MRSA and MSSA) and their relation with antibiotic resistance.

Methods: A total of 90 clinical S. aureus isolates were studied from two tertiary care hospitals. The isolates were identified by standard biochemical tests. Methicillin resistance was confirmed by oxacillin and cefoxitin resistance. Multiplex PCR was used to determine the agr groups.

Results: MRSA prevalence was found to be 53.3%.The agr groups

Author Biography

Rabaab Zahra, Department of Microbiology Quaid-i-Azam University Islamabad, Pakistan

Assistant Professor

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Published

2014-01-10

How to Cite

Khan, S., Rasheed, F., & Zahra, R. (2014). Genetic polymorphism of agr Locus and antibiotic resistance of Staphylococcus aureus at two hospitals in Pakistan. Pakistan Journal of Medical Sciences, 30(1). https://doi.org/10.12669/pjms.301.4124

Issue

Vol. 30 No. 1 (2014): January - February 2014 Pak J Med Sci

Section

Original Articles