Potential reproductive health effects and oxidative stress associated with exposure to potassium dichromate (K2Cr2O7) and magnesium sulphate (MgSO4) in male mice

Authors

  • Mahmood Rasool King Abdulaziz University, Jeddah, Saudi Arabia
  • Muhammad Imran Naseer King Abdulaziz University, Jeddah, Saudi Arabia
  • Kalsoom Zaigham Institute of Molecular Biology and Biotechnology, the University of Lahore, Lahore, Pakistan
  • Arif Malik The University of Lahore, Lahore, Pakistan
  • Umm e Habiba The University of Lahore, Lahore, Pakistan
  • Abdul Manan The University of Lahore, Pakistan
  • Mahmood Husain Qazi The University of Lahore, Pakistan
  • Muhammad Asif Balochistan University of Information Technology, Engineering and Management Sciecnes

DOI:

https://doi.org/10.12669/pjms.304.4757

Keywords:

Magnesium sulphate (MgSO4), Malondialdehyde (MDA), Oxidative stress, Potassium dichromate (K2CR2O7), Superoxide dismutase (SOD).

Abstract

Objective: To investigate the potential harmful effects of potassium dichromate and magnesium sulphate causing oxidative stress and reproductive toxicity in adult male mice model.

Methods: The experimental work was conducted on sixty male mice (Mus musculus) divided into three groups. Mice in group B and C received potassium dichromate and magnesium sulphate of 5.0 and 500 mg/Kg body weight/ml respectively, for sixty days. The blood sample was analyzed to assess oxidative stress and cellular damage.

Results: Results showed high malondialdehyde (MDA) and low levels of antioxidant enzymes [catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx)] in both potassium dichromate and magnesium sulphate administrated groups as compared to control group. Reduced number of sperm count and excessive destruction of testicular follicles, including destruction of spermatids, leydig cells and sertoli cells, were also seen in both groups.

Conclusion: We concluded from present study that potassium dichromate and magnesium sulphate causes oxidative stress by generation of reactive oxygen species (ROS) and causing DNA damage in testicular cells leading to adverse reproductive abnormalities.

doi: http://dx.doi.org/10.12669/pjms.304.4757

How to cite this:Rasool M, Zaigham K, Malik A, Naseer MI, Umm-e-Habiba, Manan A, et al. Potential reproductive health effects and oxidative stress associated with exposure to potassium dichromate (K2Cr2O7) and magnesium sulphate (MgSO4) in male mice. Pak J Med Sci 2014;30(4):819-823.

Author Biographies

Mahmood Rasool, King Abdulaziz University, Jeddah, Saudi Arabia

Center of Excellence in Genomic Medicine and Research

Muhammad Imran Naseer, King Abdulaziz University, Jeddah, Saudi Arabia

Center of Excellence in Genomic Medicine and Research

Kalsoom Zaigham, Institute of Molecular Biology and Biotechnology, the University of Lahore, Lahore, Pakistan

Institute of Molecular Biology and Biotechnology,

Arif Malik, The University of Lahore, Lahore, Pakistan

Institute of Molecular Biology and Biotechnology,

Umm e Habiba, The University of Lahore, Lahore, Pakistan

Institute of Molecular Biology and Biotechnology,

Abdul Manan, The University of Lahore, Pakistan

Institute of Molecular Biology and Biotechnology,

Mahmood Husain Qazi, The University of Lahore, Pakistan

Centre for Research in Molecular Medicine (CRIMM),

Muhammad Asif, Balochistan University of Information Technology, Engineering and Management Sciecnes

Department of Biotechnology and Informatics,

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Published

2014-06-06

How to Cite

Rasool, M., Naseer, M. I., Zaigham, K., Malik, A., Habiba, U. e, Manan, A., … Asif, M. (2014). Potential reproductive health effects and oxidative stress associated with exposure to potassium dichromate (K2Cr2O7) and magnesium sulphate (MgSO4) in male mice. Pakistan Journal of Medical Sciences, 30(4). https://doi.org/10.12669/pjms.304.4757

Issue

Vol. 30 No. 4 (2014): July - August 2014 Pak J Med Sci

Section

Original Articles