Efficacy of Methotrexate in patients with plaque type psoriasis
DOI:
https://doi.org/10.12669/pjms.305.4451Keywords:
Plaque psoriasis, Methotrexate, Efficacy, Remission.Abstract
Objective: To assess the efficacy of Methotrexate in patients with plaque type psoriasis.
Methods: This descriptive study was conducted in the department of Dermatology, Civil Hospital Karachi from September 2009 to March 2010. Seventy three patients between 18 to 50 years of age suffering from plaque type psoriasis with PASI score of >10 were included in the study after taking the informed consent. Oral methotrexate in a dose of 7.5 mg/week was given for 8 weeks. The data collected included demographic profile (age and gender), duration of disease, site of involvement, size of plaque, severity of plaque measured by Psoriasis Area and Severity Index (PASI) score before starting the treatment and at the end of treatment. Efficacy was labeled with a PASI score of <5 at the end of 8 weeks.
Results: Out of 73 patients there were 45 (61.6%) males and 28 (38.4%) females. The mean
