ERCC1, RRM1 and TUBB3 mRNA expression on the tumor response and overall survival of non-small cell lung cancer treated with platinum-based chemotherapy

Authors

  • Hongwei Qiao The Second Respiratory Medicine Department, Xinxiang Central Hospital, Xinxiang, China
  • Xiaoping Huang
  • Hua Guo
  • Yan Liu
  • Chunyan Yue

DOI:

https://doi.org/10.12669/pjms.306.5768

Keywords:

ERCC1, RRM1, TUBB3, mRNA, non-small cell lung cancer, Tumor response, Overall survival.

Abstract

Objective: We aimed to analyze the expression of ERCC1, RRM1 and TUBB3 in 305 patients with advanced non-small cell lung cancer (NSCLC) and investigate whether these genes can be used as biomarkers for predicting tumor response and clinical outcome.

Methods: Total 305 patients with unresectable and locally advanced NSCLC were collected between January 2007 and December 2008. cDNA of ERCC1, RRM1 and TUBB3 was isolated by a fluorescence-based real-time detection method.

Results: All the patients were followed up until December 2012. One hundred seventy five patients showed good response and 130 patients showed poor response to chemotherapy. 126 patients

Author Biography

Hongwei Qiao, The Second Respiratory Medicine Department, Xinxiang Central Hospital, Xinxiang, China

The Second Respiratory Medicine

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Published

2014-10-13

How to Cite

Qiao, H., Huang, X., Guo, H., Liu, Y., & Yue, C. (2014). ERCC1, RRM1 and TUBB3 mRNA expression on the tumor response and overall survival of non-small cell lung cancer treated with platinum-based chemotherapy. Pakistan Journal of Medical Sciences, 30(6). https://doi.org/10.12669/pjms.306.5768

Issue

Vol. 30 No. 6 (2014): November – December 2014 Pak J Med Sci

Section

Original Articles