Comparative study of alterations in Tri-iodothyronine (T3) and Thyroxine (T4) hormone levels in breast and ovarian cancer

Authors

  • Mahmood Rasool King Abdulaziz University
  • Muhammad Imran Naseer King Abdulaziz University
  • Kalsoom Zaigham University of Lahore, Lahore, Pakistan.
  • Arif Malik University of Lahore, Lahore, Pakistan.
  • Naila Riaz the University of Lahore, Lahore, Pakistan.
  • Rabail Alam The University of Lahore, Lahore, Pakistan.
  • Abdul Manan the University of Lahore, Lahore, Pakistan.
  • Ishfaq Ahmed Sheikh King Abdulaziz University
  • Muhammad Asif BUITEMS, Quetta. Pakistan

DOI:

https://doi.org/10.12669/pjms.306.5294

Keywords:

Breast cancer, Ovarian cancer, Thyroid hormones, Tri-iodothyronine (T3), Thyroxine (T4).

Abstract

Objective: The present study was designed to investigate variations in the levels of thyroid hormones (T3, T4) in breast and ovarian cancers patients.

Methods: A total 120 subjects were recruited (without thyroid history) divided into three groups; A, B and C. Group A as control with healthy individuals. While group B and group C were consisting of breast cancer and ovarian cancer patient respectively. Blood samples (5 ml) were taken and analyzed to estimate the levels of serum T3 (tri-iodothyronine) and T4 (thyroxin) hormones.

Results: Statistically significant difference (P=0.000* and P=0.017*) was obtained among all groups. A significant increase in T3 (P=0.000*) and T4 (0.005*) levels was observed among breast cancer patients as compared to healthy controls. While for ovarian cancer patients conflicting results were found for T3 and T4 levels in the serum i.e. insignificant difference was found in T3 (P=0.209) and T4 (P=0.050) as compared to control. Our results showed that in the breast cancer and ovarian cancer patients the thyroid hormone (T3 and T4) level has been altered from the normal ranges as compared to the normal healthy individuals.

Conclusion: We conclude that hyperthyroidism has profound effects on breast cancer and ovarian cancer cells proliferation.

doi: http://dx.doi.org/10.12669/pjms.306.5294

How to cite this:Rasool M, Naseer MI, Zaigham K, Malik A, Riaz N, Alam R, et al. Comparative study of alterations in Tri-iodothyronine (T3) and Thyroxine (T4) hormone levels in breast and ovarian cancer. Pak J Med Sci 2014;30(6):1356-1360.

Author Biographies

Mahmood Rasool, King Abdulaziz University

Center of Excellence in Genomic Medicine Research, (CEGMR)

Muhammad Imran Naseer, King Abdulaziz University

Center of Excellence in Genomic Medicine Research, (CEGMR),

Kalsoom Zaigham, University of Lahore, Lahore, Pakistan.

Institute of Molecular Biology and Biotechnology (IMBB),

Arif Malik, University of Lahore, Lahore, Pakistan.

Institute of Molecular Biology and Biotechnology (IMBB),

Naila Riaz, the University of Lahore, Lahore, Pakistan.

Institute of Molecular Biology and Biotechnology (IMBB),

Rabail Alam, The University of Lahore, Lahore, Pakistan.

Institute of Molecular Biology and Biotechnology (IMBB),

Abdul Manan, the University of Lahore, Lahore, Pakistan.

Institute of Molecular Biology and Biotechnology (IMBB),

Ishfaq Ahmed Sheikh, King Abdulaziz University

King Fahd Medical Research Center (KFMRC),

Muhammad Asif, BUITEMS, Quetta. Pakistan

Department of Biotechnology and Informatics,

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Published

2014-09-25

How to Cite

Rasool, M., Naseer, M. I., Zaigham, K., Malik, A., Riaz, N., Alam, R., … Asif, M. (2014). Comparative study of alterations in Tri-iodothyronine (T3) and Thyroxine (T4) hormone levels in breast and ovarian cancer. Pakistan Journal of Medical Sciences, 30(6). https://doi.org/10.12669/pjms.306.5294

Issue

Vol. 30 No. 6 (2014): November – December 2014 Pak J Med Sci

Section

Original Articles