Association between codon 399 polymorphism in the X-ray repair cross-complementing group 1 gene and risk of prostate cancerin Asians: A study of 4,479 cases and 4,281 controls

Abstract

Objective: The polymorphism in codon 399 of the X-ray repair cross-complementing group 1 (XRCC1) gene may subtly alter structure of DNA repair enzymes and modulate the repair capacity. Impaired DNA repair can lead to the development of cancers such as prostate cancer (PCA). Although the association between the XRCC1 codon 399 polymorphism and PCA risk has been extensively reported, the results have been ambiguous.

Methods: We conducted an updated analysis of 18 case