The healing effect of bone marrow-derived stem cells in acute radiation syndrome

Authors

  • Seyed Mohammad Javad Mortazavi Ionizing and Non-ionizing Radiation Protection Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  • Fatemeh Shekoohi-Shooli Radiology and Radiotherapy Department, Shahid Beheshti University of Medical Science, Tehran, Iran
  • Seyed Mahmood Reza Aghamir Radiology and Radiotherapy Department, Shahid Beheshti University of Medical Science, Tehran, Iran
  • Davood Mehrabani Stem Cell and Transgenic Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  • Amirreza Dehghanian Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  • Shahrokh Zare Stem Cell and Transgenic Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  • Mohammad Amin Mosleh-Shirazi Ionizing and Non-ionizing Radiation Protection Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

DOI:

https://doi.org/10.12669/pjms.323.9895

Keywords:

Acute radiation syndrome, Mesenchymal stem cell, Bone marrow, Healing, Survival, Mouse.

Abstract

Objectives: To determine the effect of bone marrow-derived mesenchymal stem cells (BMSCs) on regeneration of bone marrow and intestinal tissue and survival rate in experimental mice with acute radiation syndrome (ARS).

Methods: Forty mice were randomly divided into two equal groups of A receiving no BMSC transplantation and B receiving BMSCs. BMSCs were isolated from the bone marrow and cultured in DMEM media. Both groups were irradiated with 10 Gy (dose rate 0.28 Gy/ min) 60CO during 35 minutes with a field size of 35

Author Biographies

Seyed Mohammad Javad Mortazavi, Ionizing and Non-ionizing Radiation Protection Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Professor of Ionizing and Non-ionizing Radiation Protection

Fatemeh Shekoohi-Shooli, Radiology and Radiotherapy Department, Shahid Beheshti University of Medical Science, Tehran, Iran

Master of Radiology and Radiotherapy

Seyed Mahmood Reza Aghamir, Radiology and Radiotherapy Department, Shahid Beheshti University of Medical Science, Tehran, Iran

Professor of Radiology and Radiotherapy

Amirreza Dehghanian, Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

Professor of Pathology

Shahrokh Zare, Stem Cell and Transgenic Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Instructor of Stem Cell and Transgenic Technology

Mohammad Amin Mosleh-Shirazi, Ionizing and Non-ionizing Radiation Protection Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Professor of Ionizing and Non-ionizing Radiation Protection

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Published

2016-06-13

How to Cite

Mortazavi, S. M. J., Shekoohi-Shooli, F., Aghamir, S. M. R., Mehrabani, D., Dehghanian, A., Zare, S., & Mosleh-Shirazi, M. A. (2016). The healing effect of bone marrow-derived stem cells in acute radiation syndrome. Pakistan Journal of Medical Sciences, 32(3). https://doi.org/10.12669/pjms.323.9895

Issue

Vol. 32 No. 3 (2016): May - June 2016 Pak J Med Sci

Section

Original Articles