To compare anti-albumin urea effects of valsartan alonewith combination of valsartan and amlodipinein patients of chronic kidney disease

Authors

  • Ameen .
  • Muhammad Alii Kashif
  • Sumreen .

DOI:

https://doi.org/10.12669/pjms.323.9541

Keywords:

Albuminuria, Amlodipine, Spot urinary albumin, creatinine, Valsartan.

Abstract

Objective: To compare anti-albumin urea effects of Valsartan alone with combination of Valsartan and Amlodipine in patients of chronic kidney disease.

Methods: This randomized clinical trial was conducted at the Department of Medicine, Combined Military Hospital Bahawalpur, from April 2014 to 30 September 2014. 140 patients of chronic kidney disease with baseline blood pressure more than 140/90mmHg having raised urinary albumin: creatinine ratio (UACR). UACR more than 3.5 mg/mmol was considered abnormal. Group-A was treated with Valsartan 80mg daily and Group-B was treated with valsartan 80 and amlodipine 10mg once a day. We did not change the dose of drugs and check spot UACR at base line and after six months with therapy and compare improvement in UACR between Group-A and B. Data was analyzed by statistical software packages (SPSS 16.0).

Results: In both the groups, BP was significantly lower than the respective value. Mean decrease in spot UACR in Group-A was 3.18

Author Biography

Muhammad Alii Kashif

Consultant Medicine

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Published

2016-06-13

How to Cite

., A., Kashif, M. A., & ., S. (2016). To compare anti-albumin urea effects of valsartan alonewith combination of valsartan and amlodipinein patients of chronic kidney disease. Pakistan Journal of Medical Sciences, 32(3). https://doi.org/10.12669/pjms.323.9541

Issue

Vol. 32 No. 3 (2016): May - June 2016 Pak J Med Sci

Section

Original Articles