Pheniramine Maleate is more effective than Lidocaine on Fentanyl Induced Cough

OZGUR OZMEN; DUYGU KARA; EMINE UZLAS KARAMAN; FATMA KARAKOC; MUHAMMET AHMET KARAKAYA; ZAKIR ARSLAN

doi:10.12669/pjms.323.9496

Authors

OZGUR OZMEN Erzurum Regional Training and Research Hospital, Anesthesiology and Reanimation Department, Erzurum, TURKEY
DUYGU KARA Erzurum Regional Training and Research Hospital, Anesthesiology and Reanimation Department, Erzurum, TURKEY
EMINE UZLAS KARAMAN Erzurum Regional Training and Research Hospital, Anesthesiology and Reanimation Department, Erzurum, TURKEY
FATMA KARAKOC Erzurum Regional Training and Research Hospital, Anesthesiology and Reanimation Department, Erzurum, TURKEY
MUHAMMET AHMET KARAKAYA Erzurum Regional Training and Research Hospital, Anesthesiology and Reanimation Department, Erzurum, TURKEY
ZAKIR ARSLAN Erzurum Regional Training and Research Hospital, Anesthesiology and Reanimation Department, Erzurum, TURKEY

DOI:

https://doi.org/10.12669/pjms.323.9496

Keywords:

Fentanyl, Pheniramine Maleate, Lidocaine, Cough.

Abstract

Objective: Fentanyl is frequently used during anesthesia induction. The use of fentanyl can cause cough through different mechanisms. Here, we aimed to investigate effects of pheniramine maleate (PM), an antihistaminic agent, and compare it with lidocaine on fentanyl induced cough.

Methods: This is a randomized double-blind prospective clinical study of ASA I-II, 120 patients scheduled for elective abdominal surgery. Patients were administered drugs intravenously and randomly allocated into three groups: Group C (2 ml 0.9 % normal saline), Group L (1mg/kg lidocaine), and Group F (PM 45.5 mg). 90 seconds after administration, 2