Predictive value of stathmin-1 and osteopontin expression for taxan resistance in metastatic castrate-resistant prostate cancer

Authors

  • Asude Aksoy Firat University
  • Gokhan Artas Firat University
  • Omur Gokmen Sevindik Firat University

DOI:

https://doi.org/10.12669/pjms.333.12559

Keywords:

Osteopontin, Stathmin-1, Taxane resistance, Metastatic castrate-resistant prostate cancer, Survival.

Abstract

Objective: Several pathways are known to be activated during metastasis and treatment of cancer. We investigated the role of osteopontin (OPN) and stathmin-1 (STHMN1) in metastatic castrate-resistant (mCRPC).

Methods: We included 30 patients who received at least 6 cycles of taxane regimen for metastatic mPC in the present study. For this study retrospective data was taken from Firat University, Faculty of Medicine, Medical Oncology Department between 2009 and 2015. OPN expression and STHMN1 expression were retrospectively evaluated by immunohistochemical staining in biopsy specimens. The relationship between the expression levels of OPN and STMN1 and the response to taxane based regimen and survival was analyzed.

Results: There was mild or strong overexpression of OPN and STHMN1 in all

Author Biographies

Asude Aksoy, Firat University

Internal medicine, medical oncology

Gokhan Artas, Firat University

Pathology

Omur Gokmen Sevindik, Firat University

HEMATOLOGY

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Published

2017-06-29

How to Cite

Aksoy, A., Artas, G., & Sevindik, O. G. (2017). Predictive value of stathmin-1 and osteopontin expression for taxan resistance in metastatic castrate-resistant prostate cancer. Pakistan Journal of Medical Sciences, 33(3). https://doi.org/10.12669/pjms.333.12559

Issue

Vol. 33 No. 3 (2017): May

Section

Original Articles