In-Vitro Transcription analysis of NS5A from HCV-3a circulating in Pakistani patients with chronic hepatitis C and their differential response to antiviral therapy

Authors

  • Shameem Bhatti Atta-ur-Rahman School of Applied Bio-Sciences, Department of Healthcare Biotechnology, National University of Sciences and Technology (NUST), Islamabad 44000
  • Sobia Manzoor Atta-ur-Rahman School of Applied Bio-Sciences, Department of Healthcare Biotechnology, National University of Sciences and Technology (NUST), Islamabad 44000
  • Fahed Parvaiz 3Department of Biosciences, COMSATS Institute of Information Technology, Park Road, Chak Shahzad, Islamabad 44000
  • Javed Ashraf 4University of Eastern Finland – Kuopio
  • Farakh Javed 5University of Haripur (UOH), Khyber Pakhtunkhwa 22620

DOI:

https://doi.org/10.12669/pjms.335.12973

Keywords:

HCV genotype, NS5A, Pakistan, Viral Load, peg-IFN therapy.

Abstract

Objective: Mutations in HCV nonstructural protein 5A (NS5A) play a vital role in virus resistance. The aim of this study was to develop a correlation between NS5A mutations (genotype 3a) and virological response towards interferon alpha (IFN-?) plus ribavirin therapy.

Methods: In this study, which was conducted from 09-02-2013 to 25-11-2015 in the rural area of Province Sindh

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Published

2017-10-20

How to Cite

Bhatti, S., Manzoor, S., Parvaiz, F., Ashraf, J., & Javed, F. (2017). In-Vitro Transcription analysis of NS5A from HCV-3a circulating in Pakistani patients with chronic hepatitis C and their differential response to antiviral therapy. Pakistan Journal of Medical Sciences, 33(5). https://doi.org/10.12669/pjms.335.12973

Issue

Vol. 33 No. 5 (2017): September – October 2017

Section

Original Articles