Diagnostic utility of C-kit protein (CD117) expression in differentiating adenoid cystic carcinoma and polymorphous low grade Adenocarcinoma

Authors

  • Hassan Tariq Armed Forces Institute Of Pathology
  • Saba Anjum
  • Hafeez ud Din
  • Farhan Akhtar

DOI:

https://doi.org/10.12669/pjms.336.13373

Keywords:

Adenoid cystic carcinoma, Polymorphous low-grade adenocarcinoma, C-kit, Salivary gland neoplasm.

Abstract

Background & Objective: To evaluate usefulness of immunohistochemical marker C-kit (CD117) in differentiating Adenoid cystic carcinoma (AdCC) from Polymorphous low-grade adenocarcinoma (PLGA) in patients of salivary gland carcinomas. AdCC is a malignant salivary gland neoplasm with poor prognosis. PLGA is a salivary gland malignancy with indolent growth pattern. Differentiating between the two entities is a diagnostic challenge. We evaluated the role of C-kit in differentiating the two.

Methods: This

Author Biography

Hassan Tariq, Armed Forces Institute Of Pathology

Histopathology department, Armed forces institute of pathology, Cmh Rawalpindi

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Published

2017-12-19

How to Cite

Tariq, H., Anjum, S., Din, H. ud, & Akhtar, F. (2017). Diagnostic utility of C-kit protein (CD117) expression in differentiating adenoid cystic carcinoma and polymorphous low grade Adenocarcinoma. Pakistan Journal of Medical Sciences, 33(6). https://doi.org/10.12669/pjms.336.13373

Issue

Vol. 33 No. 6 (2017): November – December 2017

Section

Original Articles