A study on Catalase Gene Promoter Polymorphism-21 A/T (rs7943316) in Healthy Pakistani population

Authors

  • Syeda Nuzhat Nawab The Karachi Institute of Biotechnology and Genetic Engineering (KIBGE)University Of Karachi
  • Sitwat Zehra The Karachi Institute of Biotechnology and Genetic Engineering (KIBGE)University Of Karachi
  • Asher Fawwad Baqai Institute of Diabetology and Endocrinology,Baqai Medical University
  • Abid Azhar The Karachi Institute of Biotechnology and Genetic Engineering (KIBGE)University Of Karachi

DOI:

https://doi.org/10.12669/pjms.336.13188

Keywords:

Antioxidant enzyme, Catalase, Polymorphism, Promoter, Reactive oxygen species.

Abstract

Background & Objective: Catalase (CAT) is an important endogenous antioxidant enzyme that detoxifies H2O2 into water and oxygen, consequently limiting the deleterious effects of reactive oxygen species. It has suggested that CAT -21A/T (rs7943316) OMIM: 115500 gene promoter polymorphism is predominantly associated with different human disorders such as hypertension, cancers, diabetes, nephropathy, and other diseases accompanied by oxidative stress. This study was

Author Biography

Syeda Nuzhat Nawab, The Karachi Institute of Biotechnology and Genetic Engineering (KIBGE)University Of Karachi

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Published

2017-12-20

How to Cite

Nawab, S. N., Zehra, S., Fawwad, A., & Azhar, A. (2017). A study on Catalase Gene Promoter Polymorphism-21 A/T (rs7943316) in Healthy Pakistani population. Pakistan Journal of Medical Sciences, 33(6). https://doi.org/10.12669/pjms.336.13188

Issue

Vol. 33 No. 6 (2017): November – December 2017

Section

Short Communication