Efficacy of Vitamin D supplementation in achieving an early sputum conversion in smear positive Pulmonary Tuberculosis
DOI:
https://doi.org/10.12669/pjms.344.14397Keywords:
Pulmonary tuberculosis, Sputum conversion, Vitamin D.Abstract
Objective: To determine the efficacy of Vitamin D supplementation in achieving an early sputum conversion in vitamin D deficient smear positive pulmonary tuberculosis patients.
Methods: This randomized clinical trial was done at Mayo hospital Lahore from November 2015 to August 2016. One hundred twenty patients with sputum smear positive pulmonary tuberculosis were selected and randomized to Group-A (taking anti-tuberculous therapy (ATT) only) and Group-B (taking ATT with Vitamin D supplementation). Four doses of100,000 IU of Vitamin D injection intramuscularly were given after every 14 days during intensive-phase. Sputum examination was repeated at 2nd, 4th, 6th, 8th, 10th and 12th weeks. Efficacy of treatment in terms of early sputum conversion between both groups was tested using Chi square and independent sample t-test was applied to compare mean values of serum vitamin D before and after treatment. P-value ? 0.05 was considered as significant.
Results: The mean age of patients was 37.18
