Infantile Spasms: Clinical profile and treatment outcomes
DOI:
https://doi.org/10.12669/pjms.346.15869Keywords:
Epileptic Encephalopathies, Electroencephalographic, Hypsarrythmia, Myoclonic jerks, Vigabatrin.Abstract
Background and Objective: Infantile spasm (IS) is one of the severe epileptic encephalopathies which affect children in early two years of life. Our objective was to determine the clinical profile, etiology and outcome of treatment in children with infantile spasms attending tertiary care hospital at Karachi, Pakistan.
Methods: This is retrospective study of 36 patients out of 94 registered as IS, aged three months to two years, managed and followed up at Aga Khan University Hospital, Karachi, from 2010 to 2015. Data of all children with IS was collected from case record. Details including clinical observations, lab investigations, anti-epileptic medications and treatment outcome was collected and analyzed. Patients who received treatment for six weeks to document response were included. The treatment response was categorized as complete response, partial response (>50% improvement) and no response. Data was analyzed on SPSS using descriptive statistics.
Results: Thirty-six patients (38.29%) with IS fulfilled eligibility criteria. The mean
