Correlation of serum levels of Vitamin D3 with serum parathormone in nursing mothers and infants 1-6 months’ age from South Punjab, Pakistan

  • Ghulam Mustafa, Dr. The Children’s Hospital & The Institute of Child Health, Multan
  • Muhammad Khalid The Children’s Hospital & The Institute of Child Health, Multan
  • Ijaz Ahmed, Dr. The Children’s Hospital & The Institute of Child Health, Multan
  • Muhammad Abu Talib, Dr. The Children’s Hospital & The Institute of Child Health, Multan
Keywords: Calcium, Exclusive breastfeeding, Lactating Mother, Parathormone, VD3, Vitamin D

Abstract

Background and Objective: Parathormone (PTH) and serum Vitamin D3 (VD3) share a complex interplay where increased VD3 leads to a negative response on parathormone level. Our objective was to determine the correlation of parathormone (PTH) and Vitamin D3 (VD3) levels in nursing mothers and infants 1-6 months’ age from South Punjab, Pakistan.

Methods: This study is a secondary data analysis of previously conducted cross sectional study which was conducted at the Department of Pediatric Medicine, Nishtar Medical University, Multan, during August 2010 to June 2011. Study included 67 infants 1-6 months of age and 60 nursing mothers. A venous blood sample was drawn for estimation of VD3, calcium, phosphate, alkaline phosphatase, parathormone and albumin. Spearman correlation coefficient was calculated to determine the inverse correlation between PTH and VD3 levels.

Results: Mean age (in days) of the infants was 83±53.7 days whereas maternal mean age was 25.53 ± 4.12 years. Median VD3 level in infants was 20.90 ng/ml (IQR – 49.5). Median serum PTH levels were 20.90 pg/ml (IQR – 26.17). Median VD3 level in nursing mothers was 21.0 ng/ml (IQR 7.2– 43.8). Median maternal serum PTH levels were 20.89 pg/ml (IQR 2.9 – 232.4). Substantial negative relation between VD3 and parathormone in infants and mothers was not evident (r = - 0.027, p-value 0.83) and (r = 0.156, p-value 0.23) respectively. A significant positive association between infant and maternal VD3 was observed (rs –0.55, p-value < 0.001).

Conclusion: Our study affirms that the customary negative correlation between VD3 and parathormone levels does not exist.

doi: https://doi.org/10.12669/pjms.36.5.2150

How to cite this:
Mustafa G, Khalid M, Ahmed I, Talib MA. Correlation of serum levels of Vitamin D3 with serum parathormone in nursing mothers and infants 1-6 months’ age from South Punjab, Pakistan. Pak J Med Sci. 2020;36(5):1015-1019.
doi: https://doi.org/10.12669/pjms.36.5.2150

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Author Biographies

Ghulam Mustafa, Dr., The Children’s Hospital & The Institute of Child Health, Multan

Professor of Peditric Medicine

Ijaz Ahmed, Dr., The Children’s Hospital & The Institute of Child Health, Multan

Senior Registrar, Pediatric Medicine

Muhammad Abu Talib, Dr., The Children’s Hospital & The Institute of Child Health, Multan

Senior Registrar, Pediatric Medicine

Published
2020-06-27
How to Cite
Mustafa, G., Khalid, M., Ahmed, I., & Abu Talib, M. (2020). Correlation of serum levels of Vitamin D3 with serum parathormone in nursing mothers and infants 1-6 months’ age from South Punjab, Pakistan. Pakistan Journal of Medical Sciences, 36(5). https://doi.org/10.12669/pjms.36.5.2150