Celiac disease is increased in esophageal squamous cell Carcinoma

  • Bilgehan Omer Poyrazoglu
  • Ahmet Cumhur Dulger
Keywords: Carcinoma, Celiac disease, Esophageal squamous carcinoma


Background and Objective: The intercourse between Esophageal squamous cell carcinoma etc. (ESC) and Celiac disease (CD) is still a complicated subject. The purpose of this research was to define the relationship between CD and ESC, and the factors associated with CD in patients with ESC.

Methods: This research was conducted by Van University Medical Center in Turkey from 2012 to 2016. CD was identified by analyzing duodenal biopsy materials from 63 ESC patients via histopathologic examinations. Serum samples from the patients were also serologically tested to identify CD. A control group was selected from among subjects who underwent gastroduodenoscopy due to dyspepsia. Distinctions between case characteristics were evaluated with chi-square tests and t-tests for categorical and continuous factors, respectively.

Results: Of the 63 study cases, 6 (9.5%) were both histological and serological positive for CD. Of the 290 control group, 8 (2.8%) had histopathological CD and tested positive for celiac antibodies. The patients with ESC had a significantly higher prevalence of CD compared to the dyspeptic patients (p<0.001). In addition, the mean creatinine levels of ESC patients with histopathological-proven CD were higher than those without CD (p=0.026). Furthermore, ESC patients who tested positive for tTg IgA had significantly higher levels of glucose and AST than those who were negative for tTg IgA (p=0.032) and (p=0.008), respectively.

Conclusion: The present study demonstrated a statistically significant positive correlation between ESC and CD. Most remarkably, higher creatinine, glucose, and AST levels may predict CD in patients with ESC. These evidences may lead novel approaches for preventing ESC in patients with CD.

doi: https://doi.org/10.12669/pjms.37.5.2757

How to cite this:
Poyrazoglu OB, Dulger AC. Celiac disease is increased in esophageal squamous cell Carcinoma. Pak J Med Sci. 2021;37(5):1445-1450. doi: https://doi.org/10.12669/pjms.37.5.2757

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Author Biographies

Bilgehan Omer Poyrazoglu

Department of General Surgery, Private System Hospital, Kayseri, Turkey

Ahmet Cumhur Dulger

Ahmet C Dulger, assotatıon prof;Department of Gastroenterology, YuzuncuYil University ,Van/ Turkey

How to Cite
Poyrazoglu, B., & Dulger, A. (2021). Celiac disease is increased in esophageal squamous cell Carcinoma. Pakistan Journal of Medical Sciences, 37(5). https://doi.org/10.12669/pjms.37.5.2757
Original Articles