ADAM10 expression in gastric adenocarcinoma: Results of a curative gastrectomy cohort

Hüseyin Alakuş; Mustafa Kaya; Hatice Özer; Hatice Reyhan Eğilmez; Kürşat Karadayı

doi:10.12669/pjms.37.2.3613

Hüseyin Alakuş Adiyaman University Faculty of Medicine, Adiyaman
Mustafa Kaya Dr. Ersin Aslan Education and Research Hospital, Gaziantep, Turkey
Hatice Özer Cumhuriyet University Faculty of Medicine, Sivas
Hatice Reyhan Eğilmez Cumhuriyet University Faculty of Medicine, Sivas
Kürşat Karadayı Cumhuriyet University Faculty of Medicine, Sivas

DOI: https://doi.org/10.12669/pjms.37.2.3613

Keywords: ADAM10 Protein, Neoplasms, rhoA GTP-Binding Protein, Stomach Neoplasms

Abstract

Objective: Gastric cancer is among the most common human cancers with high mortality rates. ADAM10, a member of the ADAM (a disintegrin and metalloproteinase) family has also been found to be associated with gastric carcinoma and has been suggested as a potential therapeutic target. Here, we investigated the association of ADAM10 expression with prognosis in gastric adenocarcinoma patients that underwent gastric resection with D2 lymph node dissection.

Methods: Total 86 consecutive patients that underwent resection for gastric adenocarcinoma were included. Immunohistochemical ADAM10 expression and its association with clinicopathological parameters were analyzed. Univariate and multivariate analyses and survival analyses were performed using SPSS ver.22.

Results: High grade tumors, advanced stage tumors and diffuse type tumors showed significantly worse prognosis. A statistically significant association between ADAM10 expression and overall survival (OS) was observed in the univariate analysis, however, this association did not maintain its significance in the multivariate analysis. No statistically significant association was found ADAM-10 expression and clinicopathological parameters.

Conclusion: Immunohistochemical ADAM10 expression may be used as a prognostic marker in gastric adenocarcinoma, however, introduction of a standardized immunohistochemical scoring system seems to be necessary for evaluation of ADAM10 staining.

doi: https://doi.org/10.12669/pjms.37.2.3613

How to cite this:
Alakus H, Kaya M, Ozer H, Egilmez HR, Karadayi K. ADAM10 expression in gastric adenocarcinoma: Results of a curative gastrectomy cohort. Pak J Med Sci. 2021;37(2):543-549. doi: https://doi.org/10.12669/pjms.37.2.3613

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.