Evaluation of C-reactive protein and hematological parameters in smokeless tobacco users: A comparative cross-sectional study

  • Sikander Munir Memon
  • Naresh Kumar Dow University of Health Sciences
  • Aneela Atta Ur Rahman
  • Binafsha Manzoor Syed
Keywords: C-reactive protein, Cardiovascular disease, Hematological parameters, Smokeless tobacco

Abstract

Objective: To investigate the changes in levels of C-reactive protein (CRP) and hematological parameters among smokeless tobacco (SLT) users.

Methods: A comparative cross-sectional study was conducted at the community level in the coastal districts of Sindh province namely Badin, Thatta, and Sujawal from January 2017 to December 2019. The CRP and hematological parameters were evaluated by well-established methods among SLT and non-SLT users.

Results: There was a statistically significant difference between SLT users (mean CRP = 0.77) versus non-users (mean CRP = 0.18), p = <0.001. Among hematological parameters, white blood cells (SLT users median = 7.85 versus non-SLT users median = 8.50, p = 0.004), monocytes (SLT users median = 6.00 versus non-SLT users median = 6.00, p = 0.001) and erythrocyte sedimentation rate (SLT users median = 15.00 versus non-SLT users median = 10.00, p = 0.006) showed statistically significant difference.

Conclusions: Significantly elevated CRP was observed in SLT users similarly hematological parameters also showed changes. WBCs, monocytes and ESR were significantly deranged among SLT users. Further studies looking into long term effects of these changes would be helpful.

doi: https://doi.org/10.12669/pjms.37.4.3841

How to cite this:
Memon SM, Kumar N, Atta-Ur-Rahman A, Syed BM. Evaluation of C-reactive protein and hematological parameters in smokeless tobacco users: A comparative cross-sectional study. Pak J Med Sci. 2021;37(4):983-987.    doi: https://doi.org/10.12669/pjms.37.4.3841

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published
2021-05-06
How to Cite
Memon, S., Kumar, N., Rahman, A., & Syed, B. (2021). Evaluation of C-reactive protein and hematological parameters in smokeless tobacco users: A comparative cross-sectional study. Pakistan Journal of Medical Sciences, 37(4). https://doi.org/10.12669/pjms.37.4.3841
Section
Original Articles