Clinical and biochemical outcomes of Sodium-Glucose CoTransporter-2 (SGLT2) Inhibitors in Type-2 Diabetes Mellitus Patients as a fourth oral anti diabetic medicine

  • Muhammad Saleem Section of Endocrinology and Department of Medicine, Aga Khan University Hospital, Karachi, Pakistan
  • Sajjad Ali Khan Section of Endocrinology and Department of Medicine, Aga Khan University Hospital, Karachi, Pakistan
  • Zafar Aleem Suchal Aga Khan University Medical College , Karachi,Pakistan
  • Nanik Ram Department of medicine and Section of Endocrinology, Aga Khan University Hospital Karachi
Keywords: SGLT2 Inhibitors, T2DM, Weight loss

Abstract

Objectives: To evaluate the clinical and biochemical effects of (SGLT2) inhibitors as a fourth oral anti-diabetic drug in patients with Type-2 diabetes mellitus (T2DM).

Methods: In a tertiary hospital in Karachi, Pakistan, a retrospective assessment of patient medical records was conducted from January 1, 2017 to December 31, 2020.A total of one hundred patients (mean age [Standard Deviation]: 53.8 [9.63] years) with poorly controlled T2DM were included. Data was collected before the SGLT-2 inhibitor was added, as well as three and six months after the medicine was started. Weight, BMI, blood pressure (BP), HbA1c, SGPT, and Creatinine were measured at the start and during the study.

Results: There was a significant reduction in HbA1c (p-value < 0.001) with a mean reduction (MR) of 0.81+1.02% at three months and 1.07+1.11% at six months. A mean weight reduction (p-value < 0.001) of 1.83+2.32 kg at three months and 4.02+6.04 kg at 6 months, respectively, was recorded. A mean BMI reduction of 0.69+0.95 kgm-2 at three months and 2.13+3.41 kgm-2 at six months of follow up, respectively were recorded. A systolic blood pressure (SBP) also showed a significant reduction (p-value < 0.05) with a MR of 5.9+15.76 mmHg at three months and 6.37+18.33 mmHg at 6 months, respectively. Non-significant variation in creatinine and SGPT was also noted.

Conclusions: SGLT-2 is an effective oral anti-diabetic medicine that can help individuals with diabetes who are currently using glucose-lowering oral anti-diabetic medications. These medications can help diabetic patients stick to their regimen.

doi: https://doi.org/10.12669/pjms.38.5.5034

How to cite this:
Saleem M, Khan SA, Suchal ZA, Ram N. Clinical and biochemical outcomes of Sodium-Glucose CoTransporter-2 (SGLT2) Inhibitors in Type-2 Diabetes Mellitus Patients as a fourth oral anti diabetic medicine. Pak J Med Sci. 2022;38(5):1255-1259. doi: https://doi.org/10.12669/pjms.38.5.5034

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Author Biographies

Muhammad Saleem, Section of Endocrinology and Department of Medicine, Aga Khan University Hospital, Karachi, Pakistan

Fellow, Section of Endocrinology and Department of Medicine, Aga Khan University Hospital, Karachi, Pakistan

Sajjad Ali Khan, Section of Endocrinology and Department of Medicine, Aga Khan University Hospital, Karachi, Pakistan

Fellow, Section of Endocrinology and Department of Medicine, Aga Khan University Hospital, Karachi, Pakistan

Zafar Aleem Suchal, Aga Khan University Medical College , Karachi,Pakistan

Medical Student, Aga Khan University Medical College , Karachi,Pakistan

Nanik Ram, Department of medicine and Section of Endocrinology, Aga Khan University Hospital Karachi

Assistant Professor, Department of Medicine and Section of Endocrinology, Aga Khan University Hospital Karachi

Published
2022-05-17
How to Cite
Saleem, M., Khan, S. A., Suchal, Z. A., & Ram, N. (2022). Clinical and biochemical outcomes of Sodium-Glucose CoTransporter-2 (SGLT2) Inhibitors in Type-2 Diabetes Mellitus Patients as a fourth oral anti diabetic medicine. Pakistan Journal of Medical Sciences, 38(5). https://doi.org/10.12669/pjms.38.5.5034
Section
Original Articles

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