Liver and Renal Injury with Remdesivir treatment in SARS-CoV-2 Patients

  • Rabiah Sadaf Dr Ruth K.M. Pfau, Civil Hospital Karachi.
  • Faiza Sadaqat Ali Dow Medical College, Dow University of Health Sciences, Karachi, Pakistan
  • Tazeen Rasheed DUHS
  • Bader Faiyaz Zuberi Clinical Trials Unit, Dow University of Health Sciences, Karachi
Keywords: SARS-CoV-2, Remdesivir, Creatinine clearance, Liver function tests, Adverse effects


Objective: To determine the effect of Remdesivir on liver enzymes and renal functions in SARS-CoV-2 patients.

Methods: This prospective cohort study was conducted at Dr. Ruth KM Pfau, Civil Hospital Karachi between 1st December 2021 to 31st January, 2022. All patients of severe SARS-CoV-2 infection who received Inj. Remdesivir for five days as per protocol of SARS-CoV-2 management were included. Biodata of selected patients including age, gender, diabetic, hypertensive status was recorded. Patients Liver Function Tests and Serum Creatinine were performed on days 0, 3, 5, 7 and 14.

Results: This study included 85 patients, out of which 55 (64.7%) were males and 30 (35.3%) were females. Out of 85 patients, Remdesivir was stopped in 3 (3.5%) patients. Among these three patients Remdesivir was stopped in one patient on day three because of decrease in CrCl to <30 ml/min. His CrCl improved after stopping Remdesivir. In the remaining two patients, Remdesivir was stopped due to increase in ALT to greater than 10 times from normal values on day three. Similarly, in these two patients the ALT improved after stopping Remdesivir.

Conclusion: Only three patients developed adverse effects resulting in stopping of Remdesivir, however these were reversible on stopping the drug. Therefore, Remdesivir is a relatively safe drug and well tolerated in SARS-CoV-2 patients.


How to cite this: Sadaf R, Ali FS, Rasheed T, Zuberi BF. Liver and Renal Injury with Remdesivir Treatment in SARS-CoV-2 Patients. Pak J Med Sci. 2023;39(2):430-433. doi:

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

How to Cite
Rabiah Sadaf, Ali, F. S., Rasheed, T., & Bader Faiyaz Zuberi. (2023). Liver and Renal Injury with Remdesivir treatment in SARS-CoV-2 Patients. Pakistan Journal of Medical Sciences, 39(2).
Original Articles