Comparison of the Efficacy of Diclofenac 0.1% and Nepafenac 0.1% on anterior chamber cells in patients Undergoing Cataract Surgery: A prospective clinical practice trial

Adnan Ahmad; Shmas Ul Haq; Jamal Hussain; Javed Rasul

doi:10.12669/pjms.39.5.6862

Adnan Ahmad Nowshera Medical College, Nowshera
Shmas Ul Haq DHQ Hospital, Timergara
Jamal Hussain DHQ Hospital, Timergara
Javed Rasul Pak International Med. Colg. Peshawar

DOI: https://doi.org/10.12669/pjms.39.5.6862

Keywords: Anterior chamber inflammation, Aqueous cells, Cataract surgery, Topical nepafenac 0.1%, Topical diclofenac 0.1%

Abstract

Objectives: To compare the efficacy of topical Nepafenac 0.1 % and Diclofenac 0.1% eye drops in reducing the aqueous cells in the anterior chamber in an un-eventful post cataract surgery.

Methods: This prospective, clinical trial was conducted at an Eye OPD of Qazi Hussain Ahmad Medical Complex, Nowshera from January till December 2021. Ophthalmic assessment included Visual acuity (VA), slit-lamp examination, Intraocular pressure (IOP), Central macular thickness (CMT) by Optical coherence tomography (OCT) and anterior chamber-aqueous cells measurement pre-operatively and at day 1st, 2nd, 4th and 8th week post-operatively. Patients were randomly allocated to topical diclofenac 0.1% (TD) four times a day and nepafenac 0.1% (TN) three times a day for four weeks each along with topical steroids and antibiotics.

Results: Seventy patients (70) were randomly distributed into two treatment arms of 35 each. In both the arms VA improved which achieved a level of statistical significance post-operatively, however statistically insignificant difference was observed between the groups at 8th week follow up visit (p= 0.62). However, IOP and CMT values didn’t achieve statistical significance between the arms pre and post operatively. In TN arm, level of AC-cells at 2nd and 4th week post-operatively were significantly lower (10.54 ± 4.05 and 08.20 ± 4.44) than TD arm (11.28 ± 5.04 and 09. 66 ± 5.50) with statistically significant difference (p < 0.05).

Conclusions: Topical Nepafenac 0.1% was more effective in suppressing the anterior chamber inflammation as compared to diclofenac during the early few post-operative weeks.

doi: https://doi.org/10.12669/pjms.39.5.6862

How to cite this: Ahmad A, Haq S, Hussain J, Rasul J. Comparison of the Efficacy of Diclofenac 0.1% and Nepafenac 0.1% on anterior chamber cells in patients Undergoing Cataract Surgery: A prospective clinical practice trial. Pak J Med Sci. 2023;39(5):1361-1365. doi: https://doi.org/10.12669/pjms.39.5.6862

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