Mediators of Periodontitis complementing the development of Neural Disorders

  • Ayesha Sadiqa CMH Lahore Medical College
  • Munsara Khalid Khan CMH Lahore Medical College and Institute of Dentistry
Keywords: Inflammation mediators, Somatosensory Disorder, Chronic periodontitis, Cytokines, and Chemokines


As a common oral health concern, periodontitis has been a source of attention for the global health community because of its linkage with systemic and neurological diseases. The purpose of the present study is to reveal the mediating role of specific cytokines, neuropeptides, and pathogens in the association of chronic periodontitis and neural disorders. To find the related literature different search engines namely PMC, Science Direct, PubMed, Research Gate, and Google Scholar were explored for a study period of five months from October 2022 to February 2023. This review offers a summary of those neuronal diseases that were more related to human behaviors in association with chronic periodontitis. Those neuronal pathologies mainly included Alzheimer’s disease, psychosis, stress, anxiety, dementia, Alzheimer’s, major depressive disorder, and diabetic peripheral neuropathy, which may otherwise remain subside or even control in the absence of chronic periodontitis and its mediators. Specifically, periodontitis related specific cytokines i.e. IL-6, IL-1, Tumor necrosis factor alpha (TNF-α), C-reactive protein (CRP), and alpha1-antichymotrypsin, neuropeptides such as insulin-like growth factor-2 (IGF-2), neuropeptide Y, substance P, neurokinin A, calcitonin gene-related peptide (CGRP), and vasoactive intestinal polypeptide (VIP), and a polybacterial pathogenic consortium of porphyromonas gingivalis, tannerella forsythia, and treponema denticola, were involved in the mediation and exacerbation of the associated neuronal cognitive pathologies.


How to cite this: Sadiqa A, Khan MK. Mediators of Periodontitis complementing the development of Neural Disorders. Pak J Med Sci. 2024;40(1):214-221. doi:

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

How to Cite
Ayesha Sadiqa, & Khalid Khan, M. (2023). Mediators of Periodontitis complementing the development of Neural Disorders. Pakistan Journal of Medical Sciences, 40(1).