Seroprevalence of Hepatitis-E Virus-Immunoglobulin G and its association with Chronic Liver Disease

  • Muhammad Sadik Memon Asian Institute of Medical Sciences (AIMS) Hospital, Hyderabad, Pakistan
  • Bushra Kadir Asian Institute of Medical Sciences (AIMS) Hospital, Hyderabad, Pakistan
  • Lubna Kamani Liaquat National Hospital
  • Ayaz Ahmed Chandio Asian Institute of Medical Sciences (AIMS) Hospital, Hyderabad, Pakistan
Keywords: Hepatitis, HEV, Chronic liver disease, Hepatitis E vaccine, Hepatitis E

Abstract

Background & Objective: Viral hepatitis is a major public health concern in low-middle income countries. Hepatitis-E infection (HEV) is found globally but most prevalent in low-income countries especially those with poor sanitation systems, access to clean drinking water and health services. Superinfection with HEV in patients with chronic liver disease (CLD) can cause severe hepatic decompensation leading to increased morbidity and mortality. To determine the frequency of seroprevalence of Hepatitis-E virus Immunoglobulin g (IgG) and its association with chronic liver disease.

Methods: A cross-sectional study was conducted in Asian Institute of Medical Sciences, Hyderabad, Pakistan from January till May 2022. A total of 196 patients of aged ≥ 18 years, presenting in gastroenterology clinics were included in the study after informed consent.

Result: Among 196 patients, one third of patient were male (73.5%). Out of which 162 (82.7%) had liver disease and 34 (17.3%) were without liver disease. The median age of patient was 45 (33-51) years. The overall seroprevalence of HEV IgG among study population was 69.4%. HEV IgG was present in 114 and 22 in CLD and non CLD patients respectively. Multivariable regression shows no association between seroprevalence of HEV in CLD and non-CLD patient (AOR 1.02, 95% CI 0.45-2.313).

Conclusion: Our study showed high frequency of HEV seropositivity. No difference was observed in HEV seropositivity among CLD and non-CLD patients.

doi: https://doi.org/10.12669/pjms.40.5.8448

How to cite this: Memon MS, Kadir B, Kamani L, Chandio AA. Seroprevalence of Hepatitis-E Virus-Immunoglobulin G and its association with Chronic Liver Disease. Pak J Med Sci. 2024;40(5):1011-1016. doi: https://doi.org/10.12669/pjms.40.5.8448

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published
2024-04-17
How to Cite
Memon, M. S., Kadir, B., Kamani, L., & Chandio, A. A. (2024). Seroprevalence of Hepatitis-E Virus-Immunoglobulin G and its association with Chronic Liver Disease. Pakistan Journal of Medical Sciences, 40(5). https://doi.org/10.12669/pjms.40.5.8448
Section
Original Articles

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