Effect of calcium plus Vitamin-D combined with calcitriol in the treatment of patients with Type-2 diabetes and osteoporosis: A retrospective observational analysis

  • Jinxing Wan
  • Jun Xie Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou Peoples Hospital Hunan Province
  • Chaohui Hu
  • Jiahe Liu
  • Chunyan Zhu
Keywords: Calcium plus Vitamin-D, Calcitriol, Type-2 diabetes, Osteoporosis

Abstract

Objective: To explore the clinical effect of calcium plus Vitamin-D combined with calcitriol in the treatment of patients with type-2 diabetes mellitus (T2DM) patients and osteoporosis.

Methods: In this retrospective observational study clinical records of 90 patients with T2DM combined with osteoporosis, treated in The Quzhou Affiliated Hospital of Wenzhou Medical University from October 2019 to April 2022 were incuded. All patients received basic hypoglycemic treatment. Of 90 patients, 43 received calcium plus Vitamin-D adjuvant therapy (Control-group), and 47 patients received calcium plus Vitamin-D combined with calcitriol adjuvant therapy (Observation-group). Clinical efficacy, adverse reactions, bone metabolism levels, and changes in bone density levels were compared between the two groups.

Results: The clinical efficacy of the treatment was significantly higher in the Observation-group (93.6%) compared to the Control-group (83.7%; p<0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (p>0.05). After treatment, bone metabolism and bone density indicators in both groups improved, and were significantly better in the Observation-group compared to the Control-group (p<0.05).

Conclusions: Combination of calcium plus Vitamin-D and calcitriol adjuvant therapy in patients with T2DM and osteoporosis is safe and associated with better treatment efficacy, improved bone metabolism and bone density parameters than calcium plus Vitamin-D treatment alone.

doi: https://doi.org/10.12669/pjms.40.3.8795

How to cite this: Wan J, Xie J, Hu C, Liu J, Zhu C. Effect of calcium plus Vitamin-D combined with calcitriol in the treatment of patients with Type-2 diabetes and osteoporosis: A retrospective observational analysis. Pak J Med Sci. 2024;40(3):444-448.  doi: https://doi.org/10.12669/pjms.40.3.8795

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published
2023-12-29
How to Cite
Wan, J., Xie, J., Hu, C., Liu, J., & Zhu, C. (2023). Effect of calcium plus Vitamin-D combined with calcitriol in the treatment of patients with Type-2 diabetes and osteoporosis: A retrospective observational analysis. Pakistan Journal of Medical Sciences, 40(3). https://doi.org/10.12669/pjms.40.3.8795