Gamma knife radiosurgery clinical efficacy for brain stem glioma: The institutional experience

  • Aurangzeb Kalhoro Neurospinal & Cancer Care Institute
  • Kashif Ahmed neurospinal cancer care institute karachi
  • Abdul Sattar M. Hashim neurospinal cancer care institute karachi https://orcid.org/0000-0002-8847-7844
Keywords: Oncology, Gamma Knife, Brainstem glioma, Stereotactic surgery, Radiosurgery

Abstract

Objective: In the past, brain stem was treated with surgery or placement of shunt in Pakistan. Gamma Knife surgery is currently an alternative to surgery for deep brain lesions. In the current study, we show the clinical experience of our Centre treated with Gamma Knife surgery.

Methods: This is a descriptive study conducted between February 2016 and October 2021. We had total 47 patients presented with focal brainstem gliomas which were selected for Gamma knife radiosurgery at the Neurospinal and Cancer Care Institute Karachi.

Results: Clinical Response was observed among them 20 (42.55%) patients improved, 22(46.80%) were stable, while 05 (10.63%) got worse The mean duration of symptoms was 31.9(SD10.5± 3months). Karnofsky Performance Status (KPS) scores during Gamma knife radiosurgery were 90 in 24 patients (51%), 80 in 21 patients (44.6%), and 70 in two patients (4.2%). Four patients (10.6%) had received conventional radiotherapy before Gamma knife radiosurgery.

Conclusion: Among the diverse gliomas, their peril varies not just by type but also by their intricate location within the brain. The efficacy of gamma knife radiation is excellent particularly when tackling high-grade tumors, exhibiting its prowess in both adult and pediatric cases.

doi: https://doi.org/10.12669/pjms.40.10.9658

How to cite this: Kalhoro A, Ahmed K, Hashim ASM. Gamma knife radiosurgery clinical efficacy for brain stem glioma: The institutional experience. Pak J Med Sci. 2024;40(10):2176-2180. doi: https://doi.org/10.12669/pjms.40.10.9658

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Author Biography

Kashif Ahmed, neurospinal cancer care institute karachi

MBBS, FCPS

Published
2024-10-17
How to Cite
Kalhoro, A., Ahmed, K., & Hashim , A. S. M. (2024). Gamma knife radiosurgery clinical efficacy for brain stem glioma: The institutional experience. Pakistan Journal of Medical Sciences, 40(10), 2176-2180. https://doi.org/10.12669/pjms.40.10.9658
Section
Original Articles